|Application||Curcumin is a yellow-orange dye, NOS2 regulator, and inhibitor of NF-κB, 5-LO, Cox-2, COP9, and p300/CBP.|
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Refer to Certificate of Analysis for lot specific data (including water content).
Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa. Curcumin is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.
|Physical State :||Solid|
|Solubility :||Soluble in water (1 mg/ml), and ethanol (1%). Insoluble in acetone.|
|Derived From :||Turmeric rhizome|
|Solubility :||Soluble in DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (< 0.1 mg/ml), and chloroform. Insoluble in ethanol.|
|Storage :||Store at room temperature|
|Melting Point :||170-175° C|
|Boiling Point :||~591.4° C at 760 mmHg (Predicted)|
|Density :||~1.3 g/cm3 (Predicted)|
|Refractive Index :||n20D 1.42|
|IC50 :||5-lipoxygenase: IC50 = 8 µM; cyclooxygenase: IC50 = 52 µM; nitric oxide synthase in activated macrophages: IC50 = 6 µM|
|WGK Germany :||3|
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