| Application | Curcumin is a yellow-orange dye, NOS2 regulator, and inhibitor of NF-κB, 5-LO, Cox-2, COP9, and p300/CBP. |
| CAS Number | 458-37-7 |
| Purity | ≥95% |
| Molecular Weight | 368.38 |
| Molecular Formula | C21H20O6 |
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Refer to Certificate of Analysis for lot specific data (including water content).
Curcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa. Curcumin is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB, possibly through inhibition of JNK (IC50=10 μM). Curcumin blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase) (IC50=8 μM), Cox-2 (cyclooxygenase-2) (IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogues and uses.
TECHNICAL INFORMATION
| Appearance : | Powder |
| Physical State : | Solid |
| Solubility : | Soluble in water (1 mg/ml), and ethanol (1%). Insoluble in acetone. |
| Derived From : | Turmeric rhizome |
| Solubility : | Soluble in DMSO (25 mg/ml), acetic acid, 0.1M NaOH, 10mM Na2CO3, acetone, water (< 0.1 mg/ml), and chloroform. Insoluble in ethanol. |
| Storage : | Store at room temperature |
| Melting Point : | 170-175° C |
| Boiling Point : | ~591.4° C at 760 mmHg (Predicted) |
| Density : | ~1.3 g/cm3 (Predicted) |
| Refractive Index : | n20D 1.42 |
| IC50 : | 5-lipoxygenase: IC50 = 8 µM; cyclooxygenase: IC50 = 52 µM; nitric oxide synthase in activated macrophages: IC50 = 6 µM |
SAFETY INFORMATION
| WGK Germany : | 3 |
| PubChem CID : |
969516
|
| RTECS : |
MI5230000
|
| Merck Index : |
14: 2673
|
| MDL Number : |
MFCD00008365
|
| EC Number : |
207-280-5
|
| Beilstein Registry : |
2306965
|
| SMILES : |
COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O
|