|Application||Phenolphthalein is a commonly used colorimetric pH indicator|
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Phenolphthalein is a chemical that is commonly used as a colorimetric pH indicator. The compound has been observed to turn orange at pH <0, clear between pH 0-8.2, fuchsia between pH 8.2-12, and clear again at a pH above 12. It has been postulated that the mutagenic effects of Phenolphthalein at high doses can be attributed the enhancement intracellular free oxygen radicals. The compound has also been observed to induce mitotic abnormalities and micronuclei with kinetochores in vitro. In Syrian hamster embryos treated with 10-40 μM of Phenolpthalein a significant number of chromosomal aberrations occurred at the hprt locus. On human breast cancer cells Phenolphthalein has been observed to have weak estrogenic effects.
|Solubility||Soluble in water (partly), chloroform (slightly), acetone, ethanol (50 mg/ml), and methanol (10 mg/ml).|
|Storage||Store at room temperature|
|Melting Point||261-263° C (lit.)|
|Boiling Point||~557.8° C at 760 mmHg (Predicted)|
|Density||1.30 g/cm3 at 20|
|Refractive Index||n20D 1.69 (Predicted)|
|IC50||GPR55: IC50 = 6.67 µM (human)|
|Ki Data||TS: Ki= 1.2 µM (human); Thymidylate synthase: Ki= 1.4 µM (Enterococcus faecalis); Thymidylate synthase: Ki= 4.7 µM (Escherichia coli K-12); Thymidylate synthase: Ki= 4.7 µM (Lactobacillus casei)|
|pK Values||pKa: 9.7|