Rabbit anti-CHMP2B Antibody, Affinity Purified

CHMP2B

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Rabbit

Unconjugated

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

1 year from date of receipt

Human, Mouse

WB, IHC

2 - 8°C

Polyclonal

Whole IgG

Chromatin-modifying protein 2b; VPS2-2; VPS2 homolog B; vacuolar protein-sorting-associated protein 2-2; Vacuolar protein sorting-associated protein 2-2; DMT1; VPS2B; chromatin modifying protein 2B; CHMP2b; CHMP2.5; charged multivesicular body protein 2b; ALS17; hVps2-2

Primary Antibodies

Primary Antibodies

12352203

7 Days

25978

NP_054762.2

Q9UQN3

X. laevis, X. tropicalis, Chicken, Bovine, Orangutan

1:1000 - 1:5000

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1:500 - 1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

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Charged multivesicular body protein 2b (CHMP2B) is a probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UQN3].

Between 163 and C-terminus

1000 µg/ml