Rabbit anti-METTL14 Antibody, Affinity Purified

METTL14

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Rabbit

Unconjugated

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

1 year from date of receipt

Human

IP

2 - 8°C

Polyclonal

Whole IgG

hMETTL14; methyltransferase-like protein 14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14

Primary Antibodies

Primary Antibodies

12352203

7 Days

57721

NP_066012.1

Q9HCE5

Orangutan

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6 µg/mg lysate

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METTL14 forms a heterodimer with METTL3, creating an N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9HCE5].

Between 75 and 125

1000 µg/ml