Rabbit anti-TGFBR2 Antibody, Affinity Purified

TGFBR2

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Rabbit

Unconjugated

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

1 year from date of receipt

Human

IP

2 - 8°C

Polyclonal

Whole IgG

transforming growth factor, beta receptor II delta; Transforming growth factor-beta receptor type II; TGF-beta type II receptor; TGFbeta-RII; TGFR-2; transforming growth factor beta receptor II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa); transforming growth factor, beta receptor II beta; TGF-beta receptor type II; transforming growth factor, beta receptor II epsilon; transforming growth factor, beta receptor II gamma; transforming growth factor, beta receptor II alpha; LDS2B; TGF-beta receptor type-2; AAT3; FAA3; TGF-beta receptor type IIB; LDS2; MFS2; RIIC; TAAD2; tbetaR-II; TBRII; TBR-ii; LDS1B

Primary Antibodies

Primary Antibodies

12352203

7 Days

7048

NP_003233.4

P37173

Rat, Chicken

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6 µg/mg lysate

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TGF-beta type II receptor (TGFBR2) is a transmembrane serine/threonine kinase that complexes with the TGF-beta type I serine/threonine kinase receptor (TGFBR1) to form the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. The TGFBR complex transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade.The TGFBR is also involved in non-canonical, SMAD-independent TGF-beta signaling pathways [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37173].

Between 475 and 525

1000 µg/ml